New Technology To Treat Fatty Liver Disease
Fatty liver disease is a significant cause of chronic liver failure, with more than 25-30% of the worldwide population affected (data source). It is also the most common liver disease globally, affecting up to 50% of people in some parts of Europe (1).
It occurs when fatty substances called lipids build up in the liver. This leads to fatty liver and causes it to malfunction. The build-up of lipids in the liver causes it to expand. This can lead to liver fibrosis which causes scarring and scar formation. Left untreated, fatty liver disease eventually leads to chronic liver failure and death.
This condition is known as non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition where excess fat accumulates in the liver, causing the liver to become enlarged and inflamed. The condition can range from a simple accumulation of fat, which is called simple steatosis, to a more severe form known as nonalcoholic steatohepatitis (NASH).
NAFLD is typically associated with obesity, insulin resistance, and high levels of triglycerides in the blood. Other risk factors for NAFLD include diabetes, high blood pressure, and metabolic syndrome. However, NAFLD can also occur in people who are not obese or have any of these risk factors.
In its early stages, NAFLD may not cause any symptoms, and it is often detected during routine blood tests. Some people with NAFLD may experience fatigue, weakness, or pain in the upper right abdomen. As the condition progresses to NASH, it can lead to more severe symptoms such as jaundice, abdominal swelling, and confusion.
If left untreated, NASH can lead to liver fibrosis, the formation of scar tissue in the liver. This scar tissue can progress to cirrhosis, which is irreversible and can lead to liver failure. In some cases, liver cancer can develop.
Treatment for NAFLD involves lifestyle modifications such as weight loss, exercise, and a healthy diet. Medications may also be prescribed to control blood sugar levels, and cholesterol, or to reduce inflammation in the liver. In severe cases, a liver transplant may be necessary.
It’s important to note that early detection and management of NAFLD can prevent the progression of the disease and reduce the risk of serious complications. So if you suspect you may have NAFLD or are at risk for it, it’s important to speak with a healthcare professional.
The only proven treatment for fatty liver was a liver transplant until recently. Fortunately, we have now developed a groundbreaking new treatment for fatty liver disease. This article will explore the latest treatments for fatty liver disease and their potential benefits for sufferers.
What is Fatty Liver Disease
Fatty liver disease, also known as steatohepatitis and nonalcoholic fatty liver disease (NAFLD), is the most common liver disease worldwide. It occurs when too much fat builds up in the liver.
When too much fat builds up in the liver, it leads to inflammation and eventually scarring of the liver called fibrosis. Fatty liver disease often leads to chronic liver failure, which can be fatal.
Researchers have developed a new treatment for fatty liver disease in recent years: Adipose Triglyceride Lipase Inhibitor Therapies (ATL). These drugs decrease lipid accumulation in the hepatocytes and reduce hepatic steatosis. ATLs have been shown to reduce lipids by 30-40% within 2-4 weeks of starting therapy (2).
The only other proven treatment is a transplant, but this is not always available or an option due to waiting lists. Although some people fully recover from fatty liver disease with lifestyle changes and weight loss, these are not always effective for sufferers of severe cases like autism spectrum disorder or HIV/AIDS patients with co-morbidity issues.
Fatty Liver Disease Theories
There are many different theories about how fatty liver disease develops. The two main contributing theories are:
1) an excess of lipids in the body due to a high-fat diet and sedentary lifestyle, or 2) genetic defects in the liver’s ability to metabolize lipids.
It is unclear which of these drivers is more significant for developing fatty liver disease. However, it is clear that once you have fatty liver disease, it becomes hard to stop its progression toward chronic liver failure and death.
The Benefits of New Fatty Liver Treatments
The latest research has shown that a new treatment for fatty liver disease may be on the horizon. This treatment will involve using human stem cells to regenerate healthy cells in the liver and return them to a healthy state. What is most exciting about this is that it will offer sufferers of fatty liver a potential cure instead of just being able to manage the symptoms.
One of the major benefits of this new treatment is that it does not require an organ transplant. The procedure would involve extracting the patient’s stem cells from their bone marrow, then exposing them to low-dose chemotherapy or radiation therapy before returning them to the patient’s body. It’s hoped that this treatment may become available within 5 years.
Bariatric Surgery
Bariatric surgery is a type of weight loss surgery. It can be used to treat the underlying causes of fatty liver disease. Bariatric surgery is the most effective treatment for obese patients with fatty liver disease.
A recent study found that bariatric surgery, followed by aggressive lifestyle changes, reduced all-cause mortality in obese people with fatty liver disease by 40%. This research suggests that there are significant benefits to undergoing bariatric surgery. There are many different bariatric surgeries, depending on the cause and severity of the individual’s obesity (3) .
The first step in any weight loss procedure is constantly dieting and exercising. After this, an individual may be eligible for various treatments, including gastric bypass and sleeve gastrectomy. Bariatric surgery typically requires a hospital stay between 7-10 days, after which individuals can eat solid foods again and live everyday life.
Hepatic Steatosis Treatment
The new treatment for fatty liver disease is called the Hepatic steatosis treatment. It is a unique, revolutionary treatment method, and the FDA has approved it. The drug works by changing how fat is processed in the liver, removing and breaking down excess fat from the liver efficiently which would not be possible through dieting or exercise alone.
This new treatment for fatty liver disease uses ursodeoxycholic acid (UDCA), a bile acid that occurs naturally and is typically made synthetically. This medication was initially used to treat gallstones, but it can also be used to treat various conditions like primary biliary cirrhosis or Wilson’s disease.
Hepatic steatosis treatment can clear up any scarring that has occurred due to long-term fatty liver disease, which can help restore the proper functioning of the liver. This new hepatology research promises to change many lives and improve the quality of life for those who have suffered from chronic hepatic steatosis (4).
Bile Acid Sequestration
One of the newest treatments for fatty liver is bile acid sequestration. Bile acid sequestration works by trapping bile acids in the small intestine before reaching the liver. This traps and removes fat that would otherwise be deposited in the liver.
The study shows that this new treatment reduced cholesterol and triglycerides in patients, which indicates a reduction in fat levels in the liver and has a beneficial effect on the gut microbiome. It also improved insulin sensitivity, linked to fatty liver disease (5).
These results are encouraging – they show a safe and effective treatment for fatty liver disease that doesn’t involve invasive surgery or transplants.
Vascular Endothelial Growth Factor
A recent breakthrough in liver treatments is the development of vascular endothelial growth factor (VEGF) inhibitors. VEGF are proteins that stimulate blood vessels to grow. Scientists have found that too much VEGF causes fatty liver disease.
In a study, scientists tested the effects of a specific VEGF inhibitor on mice with fatty liver disease. The drug was injected into the mice every day for four weeks. After treatment, the mice had reduced triglycerides and cholesterol levels in their blood. The tests also showed that there were fewer fat cells in their livers – an indication that their fatty liver disease had improved.
This new treatment has only been tested on animals, so it is not yet available to humans, but it has enormous potential as a future treatment for fatty liver disease. It is currently being researched by pharmaceutical companies, and there is hope it will be approved for human use soon after that.
Summing it Up
Fatty liver disease is a serious condition, but it can be treated. If you are concerned about fatty liver disease, it is essential to speak to your doctor and find out if you have the condition. Treatment is available, and some treatments may help.
Get to know natural treatments for fatty liver
Fatty liver occurs when there is an excessive buildup of fat cells within the liver cells. This can lead to a buildup of fat deposits within the surrounding tissues which could potentially cause rupture if they are not dealt with appropriately. Fatty liver is a common health concern in the Western world that is often being misdiagnosed and treated incorrectly. In this article, we will discuss what fatty liver actually is, two of the most common causes of fatty liver, and how you can use a natural treatment in order to help strengthen your liver. The following are natural treatments for fatty liver;
Apple cider vinegar
This helps cleanse the liver by helping to flush out excess toxins. It also helps to reduce the buildup of fat, which will increase the size of your liver cells so that they are not overshadowed by enlarged fat deposits. You can add some apple cider vinegar to your daily meals or each day take it in a glass of water with some lemon juice squeezed into it.
Milk thistle
Milk thistle is one of nature’s most powerful herbal medicines for protecting and strengthening the liver and other vital organs, especially for people who have suffered damage within these body parts as a result of poor diet, alcohol abuse, viral infections, and pharmaceutical drug damage. The active chemical constituents in milk thistle protect the liver from damage and help to repair any existing damage. Additionally, milk thistle strengthens the liver in a couple of ways. Firstly, it helps to decrease inflammation in the liver caused by substances produced during an overactive immune response such as excess amounts of cytokines (cytokines are small proteins released by cells that aid communication between cells).
Lemon
Lemon will make your liver bright again. It also helps to increase the size of the liver cells by helping to keep toxins from building up in your liver. Lemon juice is best taken in a juice form or on a piece of bread with a fork to pierce the seeds and release all of the juice. You can also add lemon zest, lemon water, or even fresh lemons to your daily meals as they help cleanse this important organ as well.
Garlic
Garlic increases circulation in the body and helps to speed up metabolism so that you can burn off those fat deposits within your liver faster. You can also eat garlic in foods such as stir fry, pasta sauce, and even sandwiches and burgers.
Green tea
Green tea helps to flush out toxins in the liver and it also helps to strengthen a person’s immune system so that they become less susceptible to illnesses. Drinking green tea each day will also help with weight loss and increase your energy levels too. Brew 2 tea bags of green tea with some mint leaves added into boiling water for around 5-10 minutes, then leave it to cool for around 8 hours before drinking. You can either drink this as it is or add honey for taste if you want to sweeten things up a little bit more.
Cinnamon
Cinnamon is a natural herb that helps to cleanse the liver and is also good at fighting infections and reducing inflammation in the body. It also tastes delicious which makes it easy to add to even the blandest foods. In addition, cinnamon provides a lot of cardiovascular benefits as well because it helps open up your blood vessels so that your blood can flow with less resistance. Cinnamon is available in powder form or you can purchase sticks of cinnamon and grind them up yourself if you want to add more of this herb into your diet. Research also shows that cinnamon can help increase thyroid function if taken regularly according to some studies.
Bitter gourd
Bitter gourd is a natural herb that helps to cleanse your liver and is also good for aiding digestion and reducing any type of pain in the digestive tract. This is the only vegetable on this list so if you don’t like vegetables then this might not be for you. Bitter gourd tastes terrible but it can be made into a delicious juice thanks to some natural ingredients such as coconut water, lime juice, ginger, and honey. If you want all of the health benefits that bitter gourd offers then make sure that you eat it regularly as part of your daily diet.
Article Studies, References, and Resources
- Epidemiology of non-alcoholic and alcoholic fatty liver diseases
By Souveek Mitra – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063528/ - Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease By Stefano Romeo – https://www.sciencedirect.com/science/article/pii/S1550413119306679
- Association of Bariatric Surgery With Cardiovascular Outcomes in Adults With Severe Obesity and Nonalcoholic Fatty Liver Disease By Mohamed I. Elsaid, PhD, MPH – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547320/
- Quantitative Evaluation of Hepatic Steatosis Using Advanced Imaging Techniques: Focusing on New Quantitative Ultrasound Techniques
By Junghoan Park – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743150/ - Bile Acid Sequestrants for Lipid and Glucose Control By Bart Staels – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821506/
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